Table 5.

Performance Comparison of Raw OCT Measures, z Scores, and Different Threshold Definitions

Method	pRNFL for EDSS score increase		GCIP for not fulfilling NEDA-3 criteria
	C-index	Integrated Brier score	C-index	Integrated Brier score
Optimal z score cutoff	0.588 ± 0.155	0.133 ± 0.005	0.580 ± 0.161	0.164 ± 0.008
Optimal raw value cutoff	0.576 ± 0.151	0.134 ± 0.004	0.561 ± 0.149	0.166 ± 0.009
Tertile z score cutoff	0.578 ± 0.149	0.137 ± 0.005	0.563 ± 0.152	0.167 ± 0.006
Tertile raw value cutoff	0.576 ± 0.158	0.138 ± 0.006	0.559 ± 0.169	0.169 ± 0.009

Abbreviations: C-index = concordance index; EDSS = Expanded Disability Status Scale; GCIP = combined macular ganglion cell and inner plexiform layer thickness; NEDA-3 = no evidence of disease activity; OCT = optical coherence tomography; pRNFL = peripapillary retinal nerve fiber layer thickness.