Table 3.
Cross-Sectional Comparisons for Retinal Layer Thicknesses in DN-NMOSDs vs AQP4-NMOSDs and HCs
| Absolute values | DN-NMOSD vs AQP4-NMOSD | DN-NMOSD vs HC | |||||||||||||||
| DN-NMOSD | AQP4-NMOSD | HC | ON vs ON | NON vs NON | ON vs HC | NON vs HC | |||||||||||
| ON | NON | ON | NON | B | SE | p Value | B | SE | p Value | B | SE | p Value | B | SE | p Value | ||
| pRNFL [µm, mean ± SD] | 74.2 ± 21.5 | 90.3 ± 21.1 | 65.6 ± 26.9 | 97.4 ± 19.8 | 100.9 ± 9.3 | 11.2 | 8.0 | 0.173 | −4.5 | 7.9 | 0.577 | −22.7 | 4.5 | <0.001 | −10.1 | 4.4 | 0.027 |
| MV [µm, mean ± SD] | 305.3 ± 15.8 | 316.5 ± 20.7 | 292.7 ± 15.8 | 313.0 ± 16.6 | 326.0 ± 15.2 | 15.5 | 5.3 | 0.006 | 5.7 | 7.2 | 0.435 | −18.6 | 4.8 | <0.001 | −9.3 | 5.5 | 0.098 |
| mRNFL [µm, mean ± SD] | 27.1 ± 5.0 | 30.4 ± 4.2 |
25.9 ± 5.3 | 33.3 ± 4.8 |
37.1 ± 2.6 | 1.4 | 1.3 | 0.503 | −3.4 | 1.4 | 0.366 | −8.6 | 0.8 | <0.001 | −8.6 | 0.7 | 0.080 |
| GCIPL [µm, mean ± SD] | 64.3 ± 11.8 | 74.2 ± 11.8 | 60.5 ± 12.9 | 77.2 ± 11.5 | 81.2 ± 6.1 | 3.7 | 3.4 | 0.373 | −6.1 | 3.5 | 0.250 | −13.3 | 1.9 | 0.023 | −9.3 | 1.9 | 0.022 |
| INL [µm, mean ± SD] | 41.6 ± 2.6 | 41.5 ± 4.3 | 40.6 ± 4.4 | 38.7 ± 2.6 | 39.4 ± 3.2 | 1.9 | 0.9 | 0.034 | 2.8 | 1.0 | 0.543 | 1.1 | 0.7 | 0.503 | 2.5 | 0.8 | 0.302 |
Abbreviations: AQP4-NMOSD = people with aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder; B = estimate; DN-NMOSD = people with double-antibody seronegative neuromyelitis optica spectrum disorder; GCIPL = combined ganglion cell and inner plexiform layer; HC = healthy control; INL = inner nuclear layer; mRNFL = macular retinal nerve fiber layer; MV = total macular volume; NON = no optic neuritis; ON = optic neuritis; pRNFL = peripapillary retinal nerve fiber layer; SE = standard error.