FIG. 3.

Serum CDV-neutralizing antibody titers in ferrets vaccinated mucosally (i.n.) at ages 3 and 6 weeks (3w and 6w) in the presence of maternal antibody. Vaccines included i.n. NYVAC (NY-HF; n = 9) and i.n. ALVAC (AL-HF; n = 9) vectors expressing CDV H and F proteins, NYVAC-HF given via the parenteral and mucosal route at each vaccination [NY-HF (i.n./i.m.); n = 9], and the NYVAC and ALVAC vectors expressing RG (AL-RG [n = 2] and NY-RG [n = 3]) (NY/AL-RG). Ferrets were challenged i.n. with virulent CDV at 12 weeks (12w) of age. Values shown are mean ± SD inverse log₁₀ titers from samples collected just prior to vaccination (Vac.) or challenge, as indicated. Different letter superscripts at the time of challenge indicate means that are significantly different from one another (P < 0.05).