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. 2024 Apr 11;8(11):2890–2900. doi: 10.1182/bloodadvances.2024012756

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Figure 5. — GREM. (A) Pearson correlation of the vitamin B12 levels with other disease specific parameters. ∗Significant P values adjusted by Holm-Bonferroni method. (B) Receiver operating characteristic-curve for optimal cutoff assessment regarding diagnosis of indolent systemic mastocytosis (ISM) vs advanced SM (AdvSM). (C) Kaplan-Meier estimates of overall survival (OS) in patients with SM according to vitamin B12 levels (<800 U/L vs ≥800-1800 U/L vs ≥1800 U/L); ^apower = 0.948, ^bpower = 0.627. (D) Kaplan-Meier estimates of OS in patients with AdvSM (≥2000 U/L vs <2000 U/L); ^cpower = 0.586. The P values refer to the log-rank test. ANC, absolute neutrophil count; β2MG, β2-microglobulin; Eos, eosinophil count; Hb, hemoglobin; KIT, KIT D816V allele burden; MC-I, mast cell infiltration; Monos, monocyte count; Plt, platelets; WBC, white blood cells.