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. 2024 May 14;300(6):107368. doi: 10.1016/j.jbc.2024.107368

Figure 2.

Figure 2

High ASCC1 expression increases mutational load and the fraction of mutations conforming to homologous recombination deficiency.A, box plot of the number of SBSs in BRCA patients for the low (m_low, green) and high (m_high, orange) groups for ASCC1, which is overexpressed in the tumor compared to matched control, and ZNF652, whose expression does not differ between tumor and matched control. p-values from Wilcoxon tests. B, percentage of patients expressing high (m_high, above mean, tan) or low (m_low, below mean, blue) levels of ASCC1 in which single base substitutions conforming to Signature 3 from exome-wide sequencing were observed in breast invasive carcinoma (BRCA). p-value from Fisher’s exact test.