Figure 5.

GSK ameliorates high salt-accelerated arthritis progression

(A) Schematic representation of CIA model.

(B) Arthritis score of CIA mice (n = 6).

(C) Paw thickness of CIA mice (n = 6).

(D) Ankle thickness of CIA mice (n = 6).

(E) Representative pictures of the hind paw joints of CIA mice at day 42.

(F) H&E staining of ankle joints of CIA mice. Scale bars, 100 μm.

(G) The histopathological score of knee joints of CIA mice.

(H and I) The proportion of Th17 cells within splenic CD4 T cells of CIA mice (n = 6).

(J and K) The proportion of Treg cells within splenic CD4 T cells of CIA mice (n = 6).

(L and M) The proportion of activated CD4 T cells within splenic CD4 T cells of CIA mice (n = 6). Statistical significance was calculated by unpaired Student’s t test and data are represented as mean ± SD. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.