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. 2024 Jun 28;15:5497. doi: 10.1038/s41467-024-49879-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A (Left) UMAP representation of antigen-experienced PbTII cells prior to and 1, 2, and 3 days post-re-infection; two apparent trajectories indicated by arrows; GC Tfh cells and Sostdc1⁺ Tfh cells marked with dotted boundaries. (Right) Th1, Tcm, and Tfh signature scores. (Bottom) Expression patterns for various genes associated with Th1 (Cxcr6, Ifng), Tfh (Cxcr5, Bcl6), Sostdc1⁺ cells, T_CM (Ccr7, Sell, Tcf7, Klf2), and proliferation (Mki67) states. B Volcano plots depicting the number and LogFC (lfc mean) of differentially expressed genes (genes with Bayes factor > 3) from comparing Th1 cells (Left), T_CM/Tfh cells (Right), and GC Tfh cells (Bottom) prior to and post re-infection. Number of significantly upregulated/downregulated genes and the top 10 upregulated/downregulated genes annotated on volcano plots.