Comparison of baculovirus AN sequences. (A) Alignment of baculovirus sequences. Indicated are: AcMNPV (ac133) (2), CfMNPV (cfexo) (Poloumienko and Krell, unpublished), OpMNPV (op131) (1), LdMNPV (ld157) (19), and XcGV (xc145) (12). The domains conserved with the Herpesviridae AN are boxed. Dots indicate positions where all amino acids are identical, and dashes indicate gaps in the alignment. (B) Comparison of conserved domains between HSV-1 (9) and baculovirus AN. Below are shown the sequences with the consensus Baculoviridae (bac) (four out of five identical) and Herpesviridae (hpv) sequences indicated. Asterisks indicate nonconsensus amino acids. The mutations within motif II that were constructed and tested are also shown.