Table 1.
Significantly deregulated miRNAs in the psoriatic plaque epidermis (PPEpi) compared with normal psoriatic epidermis (PNEpi) (LCM)1
| MicroRNA | FHC | P-value | FDR | Total RF |
|---|---|---|---|---|
|
| ||||
| hsa-miR-223 | 10.27 | 0.00 | 0.00 | 2781 |
| hsa-miR-1307–3p | 7.64 | 0.00 | 0.00 | 3186 |
| hsa-miR-21 | 7.44 | 0.00 | 0.00 | 423 060 |
| hsa-miR-146a | 7.11 | 0.00 | 0.00 | 12 450 |
| hsa-miR-130b-3p | 6.71 | 0.00 | 0.00 | 6359 |
| hsa-miR-142–3p | 5.20 | 0.00 | 0.00 | 4266 |
| hsa-miR-192 | 4.15 | 0.00 | 0.00 | 2130 |
| hsa-miR-18a | 4.09 | 0.00 | 0.00 | 1928 |
| hsa-miR-1307 | 3.43 | 0.00 | 0.00 | 4036 |
| hsa-miR-484-RNASEN | 3.11 | 0.00 | 0.00 | 4183 |
| hsa-miR-378 | 3.03 | 0.00 | 0.00 | 30 270 |
| hsa-miR-17–3p | 2.69 | 0.00 | 0.01 | 2140 |
| hsa-miR-224 | 2.35 | 0.00 | 0.01 | 30 986 |
| hsa-miR-20a | 2.14 | 0.01 | 0.04 | 11 803 |
| hsa-miR-99a | −2.17 | 0.00 | 0.01 | 99 704 |
| hsa-miR-26b | −2.27 | 0.00 | 0.00 | 37 166 |
| hsa-miR-181a-2 | −2.34 | 0.00 | 0.01 | 21 874 |
| hsa-miR-181a-1 | −2.35 | 0.00 | 0.01 | 21 890 |
| hsa-miR-29c | −2.42 | 0.00 | 0.01 | 10 765 |
| hsa-miR-125b-2 | −2.45 | 0.00 | 0.01 | 91 490 |
| hsa-miR-125b-1 | −2.46 | 0.00 | 0.01 | 92 345 |
| hsa-miR-26a-1 | −2.94 | 0.00 | 0.00 | 72 958 |
| hsa-miR-26a-2 | −2.95 | 0.00 | 0.00 | 72 650 |
| hsa-miR-181a-2-3p | −5.35 | 0.00 | 0.00 | 4813 |
FCH, fold change; FDR, false discovery rate; PNEpi, normal psoriatic epidermis, PPEpi, psoriatic plaque epidermis; RF, read frequencies.
1
The list include deregulated miRNAs in psoriatic plaque epidermis compared with normal psoriatic epidermis. FCH > 2, FDR < 0.05. MicroRNAs in bold are novel miRNAs that have not previously been identified in psoriatic skin