Table 2.
Significantly deregulated miRNAs in psoriatic plaque dermal inflammatory infiltrates (PPRD) compared with normal psoriatic reticular dermis (PNRD) (LCM)1
| MicroRNA | FCH | P-value | FDR | Total RF |
|---|---|---|---|---|
|
| ||||
| hsa-miR-155 | 7.07 | 0.00 | 0.00 | 31 667 |
| hsa-miR-142-3p | 5.18 | 0.00 | 0.00 | 156 616 |
| hsa-miR-21-3p | 5.08 | 0.00 | 0.00 | 6316 |
| hsa-miR-142-5p | 5.07 | 0.00 | 0.00 | 57 553 |
| hsa-miR-150 | 4.97 | 0.00 | 0.00 | 78 173 |
| hsa-miR-21 | 3.98 | 0.00 | 0.00 | 4 403 103 |
| hsa-miR-150-3p | 3.60 | 0.00 | 0.00 | 1909 |
| hsa-miR-146b | 3.37 | 0.00 | 0.00 | 47 639 |
| hsa-miR-361-3p | 3.31 | 0.00 | 0.00 | 4190 |
| hsa-miR-363 | 3.31 | 0.00 | 0.00 | 2600 |
| hsa-miR-223 | 3.13 | 0.00 | 0.00 | 25 949 |
| hsa-miR-146a | 3.08 | 0.00 | 0.00 | 101 191 |
| hsa-miR-143-5p | 2.88 | 0.00 | 0.00 | 41 135 |
| hsa-miR-425 | 2.64 | 0.00 | 0.00 | 8515 |
| hsa-miR-1307 | 2.39 | 0.00 | 0.01 | 8253 |
| hsa-miR-342 | 2.24 | 0.00 | 0.00 | 29 477 |
| hsa-miR-20a | 2.09 | 0.00 | 0.02 | 20 289 |
| hsa-miR-193b | −2.08 | 0.00 | 0.02 | 7040 |
| hsa-miR-99a | −2.08 | 0.00 | 0.01 | 124 753 |
| hsa-miR-199a-1-5p | −2.16 | 0.00 | 0.00 | 255 334 |
| hsa-miR-199a-2-5p | −2.16 | 0.00 | 0.00 | 255 539 |
| hsa-miR-125b-2 | −2.32 | 0.00 | 0.00 | 251 720 |
| hsa-miR-125b-1 | −2.33 | 0.00 | 0.00 | 253 985 |
| hsa-miR-101-1-5p | −2.34 | 0.00 | 0.01 | 2895 |
| hsa-miR-365-2 | −2.39 | 0.01 | 0.05 | 1374 |
| hsa-miR-365-1 | −2.40 | 0.01 | 0.05 | 1372 |
| hsa-miR-100 | −2.43 | 0.00 | 0.00 | 132 066 |
| hsa-miR-125b-2-3p | −2.66 | 0.00 | 0.00 | 3189 |
| hsa-miR-139-3p | −2.75 | 0.00 | 0.00 | 4287 |
| hsa-miR-149 | −2.78 | 0.00 | 0.01 | 1651 |
| hsa-let-7c | −2.81 | 0.00 | 0.00 | 169 038 |
| hsa-miR-200a | −3.30 | 0.00 | 0.01 | 3486 |
| hsa-miR-141 | −3.41 | 0.00 | 0.02 | 9499 |
| hsa-miR-214-3p | −3.56 | 0.00 | 0.00 | 7468 |
| hsa-miR-200c | −4.40 | 0.00 | 0.00 | 8633 |
| hsa-miR-200b | −5.09 | 0.00 | 0.00 | 3639 |
| hsa-miR-205 | −8.08 | 0.00 | 0.00 | 30 020 |
FCH, fold change; FDR, false discovery rate; PNRD, normal psoriatic reticular dermis, PPRD, psoriatic plaque dermal inflammatory infiltrates; RF, read frequencies.
1
The list include deregulated miRNAs in psoriatic plaque dermal inflammatory infiltrates (PPRD) compared with normal psoriatic reticular dermis (PNRD). FCH > 2. FDR < 0.05. MicroRNAs in bold are novel miRNAs that have not previously been identified in psoriatic skin.