Table 1.
Demographic characteristics of normal controls and acute leukemia patients and laboratory values for acute leukemia patients at diagnosis.
| Characteristic | Normal Controls (n=30) | APL (n=29) | Non-APL AML (n=253) | ALL (n=76) |
|---|---|---|---|---|
| Sex (Male/Female) | 17/13 | 18/11 | 146/107 | 39/37 |
| Age (Median [range]) | 58.5 (23-76) | 46 (22-81) | 61 (19-89) | 56 (19-80) |
| Race | ||||
| White | 24 | 23 | 191 | 50 |
| Black | 3 | 5 | 55 | 21 |
| Asian | 0 | 1 | 3 | 0 |
| Hispanic | 3 | 0 | 1 | 4 |
| American Indian | 0 | 0 | 0 | 1 |
| Unknown | 0 | 0 | 3 | 0 |
| Bleeding | 0 | 7 (24.1%) | 31 (12.3%) | 3 (3.9%) |
| Major bleeding | 0 | 7 (24.1%) | 14 (5.5%) | 2 (2.6%) |
| Minor Bleeding | 0 | 0 (0%) | 17 (6.7%)) | 1 (1.3%) |
| VTE | 0 | 3 (10.3%) | 30 (11.9%) | 4 (5.3%) |
| DVT | 0 | 0 (0%) | 20 (7.9%) | 3 (3.9%) |
| SVT | 0 | 3 (10.3%) | 10 (4.0%) | 1 (1.3%) |
| Laboratory parameters [median (range)] | Normal range | |||
| D-dimer (ng/mL)* | <240 | 14,011 (222-20,000) | 1,049 (135-20,000) | 1,678 (233-20,000) |
| Fibrinogen (mg/dL)# | 220-498 | 208 (60-636) | 455 (60-1,101) | 387 (170-856) |
| PT (sec) | 12-14.5 | 16.5 (13.8-27.0) | 15.3 (12.9-62.4) | 14.8 (12.7-21.6) |
| PTT (sec) | 25-35 | 31 (24-200) | 34 (19-88) | 32 (24-43) |
| WBC count (x103/μL) | 4-11 | 2.7 (0.6-79.8) | 14.2 (0.4-435.9) | 15.5 (0.1-357.0) |
| Peripheral blood blast cell % | 0 | 73.0 (2.6-89.0) | 58.5 (0-96.0) | 62.8 (1.6-97.0) |
| Platelet count (x 103/μL) | 150-400 | 30.9 (7.1-131.6) | 50 (3.4-862.4) | 40.9 (7.9-377.3) |
| Creatinine (mg/dL) | 0.4-1.2 | 0.9 (0.5-4.4) | 0.9 (0.4-3.2) | 0.9 (0.4-2.2) |
| Hemoglobin (g/dL) | 13.5-17.5 | 8.6 (3.6-12.4) | 8.8 (2.9-15.1) | 8.4 (4.6-17.9) |
| LDH (Unit/L) | 120-240 | 289 (113-1,898) | 426 (109-5,469) | 477 (119-6,374) |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; APL, acute promyelocytic leukemia; CBC, complete blood count; DVT, deep vein thrombosis; LDH, lactate dehydrogenase; PT, prothrombin time; PTT, partial thromboplastin time; SVT, superficial vein thrombosis; VTE, venous thromboembolism; WBC, white blood cell
*
Maximum value of detection for d-dimer is 20,000 ng/mL.
#
Lowest limit of detection for fibrinogen was 60.