Table 4.
Biomarkers associated with deep vein thrombosis risk in acute leukemia.
| Biomarker# | Univariable | Multivariable analysis* |
|---|---|---|
| sHR (95% CI) | sHR (95% CI) | |
| EVTF activity | 1.11 (0.46 - 2.71) | 1.15 (0.46 - 2.92) |
| PS + EVs | 1.09 (0.45 - 2.64) | 1.13 (0.47 - 2.71) |
| cfDNA | 0.56 (0.25 - 1.26) | 0.61 (0.26 - 1.41) |
| H3Cit-DNA complexes | 0.75 (0.32 - 1.77) | 0.66 (0.28 - 1.56) |
| PAP | 0.75 (0.32 - 1.74) | 0.87 (0.36 - 2.10) |
| tPA | 0.53 (0.24 - 1.20) | 0.48 (0.19 - 1.24) |
| PAI-1 | 2.43 (0.83 - 7.13) | 3.00 (0.95 - 9.47) |
| D-dimer | 0.72 (0.31 - 1.69) | 0.98 (0.36 - 2.66) |
| Fibrinogen | 0.81 (0.35 - 1.85) | 0.60 (0.26 - 1.42) |
| PT | 1.46 (0.58 - 3.68) | 1.51 (0.62 - 3.65) |
| PTT | 1.38 (0.55 - 3.48) | 1.30 (0.49 - 3.44) |
| WBC count | 0.96 (0.41 - 2.24) | 0.80 (0.34 - 1.92) |
| Peripheral blood blast cell | 0.57 (0.23 - 1.39) | 0.80 (0.30 - 2.14) |
| Platelet count | 1.46 (0.58 - 3.69) | 1.49 (0.57 - 3.89) |
| Creatinine | 1.11 (0.44 - 2.79) | 1.39 (0.51 - 3.79) |
| Hemoglobin | 1.50 (0.59 - 3.80) | 1.38 (0.52 - 3.64) |
| LDH | 0.90 (0.38 - 2.13) | 0.79 (0.33 - 1.89) |
Biomarkers were considered as tertiles, and third and second tertile distributions were compared to the first tertile, and adjusted for clinically relevant covariates in multivariable models.
Multivariable model was adjusted for age, sex, race/ethnicity, leukemia type, body mass index, history of venous thromboembolism and comorbidities.
Abbreviations: cfDNA, cell-free DNA; EVTF, extracellular vesicle tissue factor; H3Cit-DNA, citrullinated histone H3-DNA; LDH, lactate dehydrogenase; PAI-1, plasminogen activator inhibitor-1; PAP, plasmin-antiplasmin complex; PS+EVs, phosphatidylserine-positive extracellular vesicles; PT, prothrombin time; PTT, partial thromboplastin time; tPA, tissue plasminogen activator; WBC, white blood cell; 95% CI, 95% confidence interval