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. 2024 Jun 17;15:1417007. doi: 10.3389/fendo.2024.1417007

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Copyright © 2024 Wang, Wang, Liu, Wang, Wang, Yue, Zhao, Wang and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial OXPHOS and ROS production in ovarian aging. In the process of ovarian aging, the balance between oxidation and antioxidant systems is disrupted. Mitochondria display aberrant OXPHOS that produces excessive amounts of ROS that damage lipids, proteins and DNA, specially telomeric regions. And reduced ATP level activates AMPK leading to cell cycle arrest and senescence induction. Oxidative phosphorylation (OXPHOS), AMP-activated protein kinase (AMPK), Reactive Oxygen Species (ROS), superoxide (·O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (·OH), Retinoblastoma protein (Rb).