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Mitochondrial quality control in ovarian aging. During ovarian aging, there is a discernible deterioration in mitochondrial quality control, characterized by enhanced mitochondrial biogenesis, a shift in dynamics favoring fusion over fission, and a decrease in mitophagy. Asa a consequence, senescent ovarian cells display an increased mitochondrial mass and mitochondria with a hyperfused and elongated morphology. Mitofusin 1 (Mfn1), Mitofusin 2 (Mfn2), Dynamin-related protein 1 (Drp1).
