Table 2.

Differences in sleep status between LTC-022 and control groups Sleep quality was measure by Pittsburgh Sleep Quality Index, and Insomnia severity was by Insomnia Severity Index.

Variables	LTC-022	Control	p-value	p-interaction†
Sleep quality
Baseline	9.7 (2.43)	10.8 (2.86)	0.198a	0.621
Week 4	6.75 (2.34)*	7.9 (2.83)*	0.340b
Week 8	6.55 (2.48)*	6.95 (2.96)*	0.847b
Insomnia severity
Baseline	13.0 (4.30)	14.2 (3.16)	0.322a	0.676
Week 4	8.60 (3.78)*	10.75 (4.61)*	0.211b
Week 8	7.25 (3.68)*	9.4 (5.71)*	0.282b

^† Two-way repeated-measures ANOVA analysis (Time [Baseline, Week 4 and Week 8] × Group [LTC-022 and Control]).

^* p-value < 0.05 are based on paired t-tests between the parameters “Week” and “baseline” in each group.

^ap-values are based on two-sample t-tests between the LTC-022 and Control groups in the baseline.

^bp-values are based on ANCOVA analysis adjusted for baseline values of each outcome variable.