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With acid hyposecretion (left), the main effect of H pylori gastritis affecting the gastric body is to suppress parietal cells, leading to low acid secretion, which is associated with gastric cancer. With acid hypersecretion (right), antral H pylori gastritis increases acid secretion by suppressing somatostatin and elevating gastrin release, increasing the risk of duodenal ulceration. Orange areas indicate extent and location of gastritis
