Table 2.
Final population pharmacokinetic model for intranasal naloxone.
| Parameter | Final Parameter Estimate | Magnitude of Variability | |||
|---|---|---|---|---|---|
| Population Mean | %RSE | Final Estimate | %RSE | ||
| CL/F | Apparent clearance (L/h) | 396 | 5.50 | 39.1%CV | 22.4 |
| Vc/F | Apparent volume of distribution, central compartment (L) |
65.7 | 24.0 | 240%CV | 22.6 |
| Q/F | Apparent clearance of distribution (L/h) | 284 (fixed) 1 | - | - | - |
| Vp/F | Apparent volume of distribution, peripheral compartment (L) |
102 (fixed) 1 | - | - | - |
| KA | First-order absorption rate constant (1/h) | 0.998 | 10.6 | - | - |
| D2 | Zero-order absorption duration (h) | 0.689 | 3.67 | - | - |
| FK0 | Fraction of dose with zero-order absorption | 0.183 | 23.1 | 151%CV | 30.1 |
| ALAG1 | Lag-time of first-order absorption (h) | 0.0717 | 1.82 | - | - |
| σ2 | Residual variability | 0.104 | 12.2 | 32.3%CV | - |
%CV, coefficient of variation expressed as a percentage; %RSE, relative standard error expressed as a percentage.
1Population means of Q/F and Vp/F were fixed to values estimated by Yassen et al. (30).