Table 5.
Overview of studies reporting on ART with own oocytes in women with Turner syndrome.
| Study type | Authors | N | Procedure | Age (years)a | Karyotype | Karyotype analysis b | AMH a (ng/ml) | FSH a (IU/l) | AFC a | Stimulation cycles | MII-oocytes a | Embryos | CPR (%) | LBR (%) | MR (%) | CA | Remarks | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retrospective cohort | Doğer et al. (2015) | 10 | ICSI | NR | NR | 100 | NR | NR | NR | 35 | NR | NR | 5/82 (6.1%) | 2/82 (2.4%) | 3/5 (60%) | NR | ||
| Giles et al. (2020) | 56 | IVF-PGT | 38.2 (37.3 –39.0) | Mosaic | 56 | NR | NR | NR | NR | 65 | 9.1 (7.8 –10.4) | 256 | 13/31 (42%) | 7/31 (22.5%) | 4/13 (31%) | 0 | ||
| Gungor et al. (2021) | 98 | ICSI (-PGT) | 33.2 ± 4.2 | 45,X/46,XX | 55 | 100 | NR | 7.3 ± 1.0 | 8.1 ± 3.3 | 98 | NR | NR | 12/NR | 9/NR | 5/12 (29%) | 0 | Additional genotyping with FISH. | |
| Other | 43 | 17/NR | 9/NR | 8/17 (47%) | ||||||||||||||
| Liao et al. (2021) | 67 | ICSI-PGT | 35.4 ± 5.8 | 45,X | 4 | 60–100 | 3.2 ± 3.4 | NR | 13.5 ± 9.5 | 100 | NR | 213 | 22/30 (73%) | 19/30 (63%) | 3/22 (14%) | NR | ||
| 45,X/46,XX | 51 | |||||||||||||||||
| Other | 12 | |||||||||||||||||
| Acet et al. (2022) | 36 | ICSI | 36.2 ± 1.9 | 45,X[≥10%]/46,XX | 10 | NR | NR | 6.7 ± 1.2 | 10.2 ± 1.4 | 36 | 6.8 ± 0.4 | 5.2 ± 0.4 | NR | 11/36 (30%) | NR | NR | Genotyping with FISH on 400 cells. | |
| 35.5 ± 0.9 | 45,X[<10%]/46,XX | 26 | NR | 5.7 ± 0.7 | 10.9 ± 1.0 | 9.4 ± 1.6 | 6.4 ± 1.3 | NR | (31%) | NR | ||||||||
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| Case report | Moore et al. (2008) | 1 | ICSI/IVF | 28 | 45,X[5]/46,XX[25] | 30 | NR | 7.3 | NR | 4 | 9 (total 36) | 18 (50%) | 0/7 | 0/7 | – | – | TS-diagnosis after 3 cycles | |
| Manno et al. (2009) | 1 | ICSI-PGT | 33 | 45,X[390]/47,XXX[10] | NR | 0.53 | 8–10 | NR | 2 | 2–3 (total 5) | 0–3 | 1/1 | 2/1 | – | NR | Genotyping with FISH on 400 cells. | ||
| Murakami et al. (2014) | 1 | OI | 38 | 45,X[14]/46,XX[16] | 30 | NR | 3.5 | NR | 9 | – | – | 2 | 1 | 1 | 0 | Mole pregnancy | ||
| Brouillet et al. (2023) | 1 | ICSI | 29 | 45,X[87]/46,XX[13] | NR | 1.78 | 7.6 | 11 | 2 | 3–7 (total 10) | 6 | 1/3 | 0/3 | 1/1 | – | |||
a
Mean±SD or Median (range).
b
Number of lymphocytes used for conventional blood karyotyping.
AFC, antral follicle count; AMH, anti-Müllerian hormone; CA, congenital abnormality of live birth; CPR, clinical pregnancy rate per embryo transfer; LBR, live birth rate per embryo transfer; MII, metaphase II oocyte; MR, miscarriage rate per clinical pregnancy; N, number of cases; NR, not reported; OI, ovulation induction; PGT, pre-implantation genetic testing; TS, Turner syndrome.