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. 2024 May 24;27(6):110108. doi: 10.1016/j.isci.2024.110108

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Changes in body weight and blood glucose levels in HFD/STZ-induced diabetic model rats

(A) Body weight changes in control rats and HFD/STZ-induced diabetic model rats were not significant.

(B) After STZ injection, the blood glucose concentration in the HFD/STZ group was significantly greater than that in the control group on day 28.

(C) Fasting blood glucose levels in the control group and HFD/STZ group. The fasting blood glucose level in the HFD/STZ group was significantly greater than that in the control group.

(D) According to the insulin tolerance test, HFD/STZ model rats were not sensitive to insulin and showed insulin resistance.

(E) According to the glucose tolerance test, blood glucose levels in the HFD/STZ group were greater than those in the control group.

(F) The area under the curve (AUC) for the glucose tolerance test was significantly greater in the HFD/STZ group than in the control group. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (n = 8 in each group). Data are represented as mean ± SD.