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PP2C family protein phosphatases regulating the hematopoiesis. PPM1B and PPM1K promote self-renewal of hematopoietic stem cells (HSC) through activating WNT/b-catenin and MEIS2 pathways, respectively. In contrast, PPM1D promotes differentiation of HSC by modulating MTOR, p53 and NOTCH pathways. In addition, PPM1B regulates production of B cells but, surprisingly, is not needed in myeloid lineage.
