Table 1.
Top-ranked alleles in the HLA-WAS on the US prospective cohort
| Allele | OR [95% CI]a | Raw p valueb | AFc | Asymptomatic definitiond |
|---|---|---|---|---|
| DRB1∗16:01 | 0.06 [0.002–1.5] | 0.004 | 0.012 | Max 2 days |
| A∗32:01 | 2.19 [1.3–3.8] | 0.008 | 0.035 | Max 2 days |
| B∗07:02 | 1.58 [1.1–2.3] | 0.016 | 0.13 | Max 2 days |
| C∗07:02 | 1.53 [1.1–2.2] | 0.020 | 0.14 | Max 2 days |
| DQB1∗06:02 | 1.52 [1.1–2.2] | 0.025 | 0.14 | Max 2 days |
| DQB1∗05:02 | 0.29 [0.1–1.1] | 0.037 | 0.015 | Max 2 days |
a
Odds ratio (OR) of being asymptomatic, i.e., OR >1 indicates that the allele is more frequent in asymptomatic individuals. CI = confidence interval.
b
Significance threshold after Bonferroni correction for multiple testing is 0.00048. Alleles shown are those with a raw p value <0.05.
c
Allele frequency (AF) is based on the frequency of the allele in the US prospective cohort “Max 2 days” analysis because this analysis included the largest numbers of cases and controls.
d
For each allele, the top-ranked result across the three asymptomatic definitions in the US prospective cohort is given.