Table 4.
Odds ratio for the association of HLA-B∗15:01 with asymptomatic SARS-CoV-2 infection in both cohorts and in the meta-analysis
| Analysis | AF asymptomatic casesa | AF symptomatic controlsa | OR [95% CI]b | Raw p value |
|---|---|---|---|---|
| US prospective cohort | 0.067 | 0.063 | 0.96 [0.58–1.6] | 0.89 |
| CHGE cohort | 0.024 | 0.030 | 0.74 [0.36–1.53] | 0.42 |
| Meta-analysis M3 | – | – | 0.88 [0.58–1.34] | 0.56 |
a
Allele frequencies (AF) are based on the frequency of the allele in the US prospective cohort “Max 2 days” analysis and in in the CHGE European cohort “Mild + Moderate” analysis, combined in the meta-analysis M3.
b
Odds ratio (OR) of being asymptomatic, i.e., OR >1 indicates that the allele is more frequent in asymptomatic individuals. CI = confidence interval.