Figure 7.

Analysis of paired NP swabs from 1-year-old children presenting for well visits. (A) NP swabs were collected from 1-year-old children (n = 20) presenting to the pediatric clinic for well visits. One NP swab was collected at the time of the appointment, and a second NP swab was collected 7–14 days later from the same children. Children were separated into three groups based on respiratory viral panel results: Group 1 includes children who experienced the acquisition of or increase in viral load between the first and second visits (n = 6); Group 2 includes children who experienced a decrease in viral load between the first and second visits (n = 10); Group 3 includes children who were virus-negative on both visits (n = 4). (B) Dynamics of respiratory viral panel results are shown as an alluvial diagram for each group of 1-year-old children for NP swabs taken on the first and second visits. (C) Log₁₀ viral load (based on Ct value relative to detection limit) is shown for each group of children. (D–F) Cytokine protein concentrations are plotted for each group as a Log₁₀ pg/ml transformed values for CXCL10 (D), IL-1β (E), and TNF (F). Paired samples are analyzed using the Wilcoxon signed-rank test on non-scaled cytokine concentrations. ns: not significant (P > 0.05); *: P = 0.0312; **: P = 0.0059.