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. 2024 Jun 3;213(2):214–225. doi: 10.4049/jimmunol.2400007

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FIGURE 1. — CCR2+ve and CCR1/2+ve monocytes are transcriptionally distinct. (A) Pie chart showing the proportion of CCR1/2+ve monocytes (green/red) and CCR2+ve monocytes (red) within the total bone marrow monocyte population. These data were obtained from flow cytometric analysis of REP mouse peripheral blood monocytes. (B) Principal component analysis of bulk RNA-seq data from bone marrow–derived CCR1/2+ve monocytes and CCR2+ve monocytes. (C) (i) Bar graph demonstrating the number of up- and downregulated genes expressed by CCR1/2+ve monocytes versus CCR2+ve monocytes. (ii) Heatmap demonstrating distinct gene expression patterns in CCR1/2+ve monocytes and CCR2+ve monocytes. (D) Box plot showing association of CCR1/2+ve monocytes with a neutrophilic transcription profile. This was obtained by entering the top 200 genes, preferentially expressed in CCR1/2+ve monocytes, into the engine server using the MyGeneset program, which analyzes transcript expression across immune and stromal cell populations.