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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2023 Aug 25;153(4):879–893. doi: 10.1016/j.jaci.2023.08.017

FIG 2.

FIG 2.

Type 2 inflammation and sensory neurons: bidirectional cross talk. Stimulated neurons produce neuropeptides that can modulate the activity of immune cells, including the production of inflammatory mediators that can directly affect sensory neurons. IL-13Rα1, IL-13 receptor-α 1; IL-31RA, IL-31 receptor A; IL-33R, IL-33 receptor; MrgprCr11, Mas-related family of G protein-coupled receptor 11; MRGPRX1, Mas-related family of G protein-coupled receptor X1; Nav, voltage-gated sodium channel; NMU, neuromedin U; PAR2, protease activated receptor 2; TSLPR, thymic stromal lymphopoietin receptor.