Table 5.
Stability studies
| Compound | Nominal concentration (ng/mL) | Freeze/Thaw between - 80°C and RT | Autosampler at 10°C | Benchtop at RT | Long-term stability | |||
|---|---|---|---|---|---|---|---|---|
| 1 F/T | 2 F/T | 3 F/T | 24h | 72h | 4h | 72 days | ||
| Bictegravir | 0.15 | 103.9 (4.5) | 97.6 (13.2) | 89.0 (4.3) | 86.4 (2.2) | 91.7 (8.4) | 92.4 (4.1) | 104.5 (6.4) |
| 40 | 91.3 (1.0) | 105.0 (2.6) | 109.5 (1.0) | 105.7 (2.7) | 112.4 (2.4) | 92.0 (2.1) | 101.7 (8.5) | |
| Cabotegravir | 0.15 | 105.8 (6.5) | 93.8 (7.7) | 91.5 (2.1) | 86.4 (2.3) | 107.7 (2.1) | 90.6 (4.4) | 96.6 (4.4) |
| 40 | 93.2 (1.0) | 110.3 (3.1) | 107.1 (2.5) | 104.1 (3.5) | 101.1 (3.0) | 85.3 (1.4) | 113.3 (3.9) | |
| Dolutegravir | 0.15 | 106.2 (6.7) | 100.6 (9.3) | 93.3 (1.7) | 87.9 (2.1) | 106.0 (5.5) | 92.9 (6.5) | 104.4 (5.7) |
| 40 | 95.2 (1.0) | 108.9 (2.9) | 114.5 (1.4) | 109.6 (0.9) | 113.6 (1.9) | 88.8 (2.6) | 104.8 (9.0) | |
| Doravirine | 0.15 | 104.4 (0.7) | 91.9 (7.2) | 99.6 (11.4) | 85.5 (4.7) | 93.5 (5.5) | 100.2 (6.4) | 100.4 (6.3) |
| 40 | 95.2 (1.8) | 108.4 (3.6) | 107.8 (3.8) | 106.8 (1.9) | 108.3 (1.0) | 93.6 (3.0) | 99.8 (1.7) | |
| Raltegravir | 0.15 | 111.4 (5.3) | 94.0 (4.8) | 94.8 (5.0) | 94.7 (5.5) | 108.9 (3.0) | 102.2 (1.4) | 111.4 (5.4) |
| 40 | 100.0 (1.5) | 109.3 (3.4) | 112.5 (3.5) | 103.0 (2.5) | 106.8 (0.6) | 87.9 (2.2) | 109.2 (7.6) | |
Data are mean percent recoveries (CV%). N=3 for each stability study.