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Model structure of compound 15 (ARN25499, panel A) and 20 (ARN25375, panel B) compounds bound to the allosteric drug-binding pocket of CDC42 is reported. The structure of CDC42 is represented as a white surface while the identified drug-binding pocket is shown in both stick and transparent blue surface. 15-ARN25499 and 20-ARN25375 are reported as yellow and green sticks, respectively.
