TABLE 2:
Factors important for antibody secretion and/or survival
| Expressed in or important for |
|||||
|---|---|---|---|---|---|
| Factor/gene | B cells | MZ cells | FO cells | LLPC | Comments |
| ABF1, GCN5 | + | Blocks further development if not shut off | |||
| ELL3 | + | On from stem cells stage, shut off after stimulation | |||
| EBF1 | + | + | + | Mediates choice of MZ vs FO fate | |
| TLRs, CD19/21 | + | Engagement actives cells | |||
| Bcl3 | + | Mediates choice of MZ or FO fate | |||
| CD40:CD40L | + | Interactions help activate cells | |||
| CHOP | + | + | + | Turns off Bcl2, turns on Atg5 | |
| Cytokines, BCR, NF-kB | + | + | + | Important for activation and survival | |
| IRF4, Blimp-1 | + | + | + | Help shut off Bcl6, pax5 | |
| ELL2 | + | + | + | Drives Igh secretory mRNA, UPR, BCMA, involved in hypoxia | |
| XBP1 | + | + | + | mRNA spliced by IRE1P to make transcription factor for UPR genes | |
| Zbtb20 | + | + | + | Promotes NF-kappaB activation | |
| CB2 stimulation | + | + | ? | Necessary for secretion, effects on survival not measured | |
| HDAC2 deletion | + | + | ? | Done with chicken DT40 cells, effects on survival not measured | |
| mTOR | + | + | ? | Necessary for secretion, effects on survival not measured | |
| Atg5 | + | Important for autophagy | |||
| BCMA | + | Induces MCL-1, an anti-apoptotic protein | |||
| CXCR4:CXCL12 | + | Important for retention in bone marrow | |||
| CD73 | + | + | Converts extracellular nucleosides to adenosine | ||
| hypoxia | ? | + | Promotes CD73 expression, modulates metabolism | ||
| Kruppel-like factor 2 | + | + | Control beta integrin expression | ||
MZ are marginal zone B cells, FO are follicular B cells, LLPC are long-lived plasma cells. See text for references and details.