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. 2024 Jun 28;13(1):2371556. doi: 10.1080/2162402X.2024.2371556

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Gene expression analysis of tumor-specific CD8⁺ T cells from MPE.

a. All identified TCR clones (n = 29) with the five tumor-antigen specific TCRs (ex1, ex7, ex12, ex17, and ex321) were projected onto UMAPs. b. Expression of exhaustion-related genes in each tumor-specific T cell clone. c. Expression of representative genes in tumor-specific T cells expressing different TCRs compared with the other T cells. Comparison of average expressions of tumor-specific T cells and the others was performed using Mann–Whitney U-test. d. Analysis of genes differentially expressed between tumor-specific T cells and other T cells. Volcano plot showing differentially expressed genes with adjusted p value < .01 and log2FC >0.5. e. Fast Gene set enrichment analysis (FGSEA) of tumor-specific T cells and others. The top 20 significant gene sets with adjusted p value < .01 and NES < 7.5 are shown. *, P < .05; **, P < .01; ***, P < .001; ****, P < .0001; ns, not statistically significant.