FIG. 1.

Alignment of HIV-1, HIV-2, and SIV Vpr genes. The sequences are as downloaded from the online server site (hiv-web.lan1.gov), with modifications. All potential phosphorylated amino acid residues are underlined and printed in bold. The putative CKII domain, TYGD, is double underlined. LR indicates a leucine-rich region. HIV-1-A, -B, -C, -D, -F, -H, -O, and -U are the consensus sequences from each HIV-1 subtype. HIV-2-A and -B are the consensus sequences from HIV-2 subtypes. SIV-CPZ, SIV-SD, and SIV-STM represent the consensus sequence for SIV subtypes. NL4-3 is the Vpr sequence from HIV-1 NL4-3, and HIV-2(ROD) shows the Vpr sequence from HIV-2 ROD. −, sequence is the same as shown for HIV-1 NL4-3 or HIV-2 (ROD); ., a gap for that position; ?, no residue homologous to the consensus sequence.