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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Ann N Y Acad Sci. 2023 Jun 30;1526(1):50–58. doi: 10.1111/nyas.15033

Figure 2. INO1 transcriptional states.

Figure 2.

Long-term repressed INO1 localizes in the nucleoplasm and is neither associated with RNAPII nor H3K4 methylation. Upon activation, INO1 is recruited to the nuclear pore complex (NPC) through the action of the Put3 and Cbf1 TFs (red proteins), which bind to cis-acting DNA zip codes upstream of INO1. Upon transcriptional repression, INO1 remains associated with the NPC. During memory, interaction with the NPC requires different factors: the Sfl1 TF and the nuclear pore protein Nup100. This interaction leads to changes in chromatin modifications (H3K4me2 and H2A.Z incorporation; indicated in blue) and recruitment of a pre-initiation form of RNAPII.