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. 2024 May 1;38(9-10):455–472. doi: 10.1101/gad.351698.124

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© 2024 Crain et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — l(3)mbt, Set8, and H4^K20R transcriptomes are similar. (A–C) Volcano plots depicting the relationship between log₂FC (x-axis) and log₁₀ adjusted P-value (y-axis) of gene expression in the indicated comparisons. Blue dots indicate significantly downregulated genes (log₂FC < −1 and FDR < 0.01), and red dots indicate significantly upregulated genes (log₂FC > 1 and FDR < 0.01). Darker-shaded dots indicate genes in the high H4K20me1 category. (D) Clustered heat maps of average centered normalized counts in the indicated genotypes. (E) Heat map of log₂FC values of the indicated genotypes for genes involved in MBT formation (Janic et al. 2010).