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Potential pathomechanisms of how pathogenic variants in genes involved in kidney development contribute to FSGS. The multifactorial pathogenesis of FSGS caused by deleterious SNVs in nephrogenesis genes consists of intrinsic podocytic factors, impaired podocyte endowment, and biomechanical stress on the glomerular environment. Displayed is a cross section of the glomerular capillary loop (inlay) with podocytes (yellow), glomerular basement membrane (purple), and endothelial cells (red).
