Table 1.
Study characteristics
| Study | Country | Characteristics of total ADPKD cohort | ADPKD patients with RCC, n | ADPKD kidneys with RCC, n | Incidental RCCs, n (%)** | RCC subtypes | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| patients, n | proportion with ESRD, % | kidneys analysed, n | proportion male, % | mean age, years | clear cell, n (%)** | papillary, n (%)** | other, n (%)** | |||||
| Asimakopoulos et al. [16] (2015) | Italy | 19 | 100 | 19 | 42 | 53 | 0 | 0 | – | – | – | – |
| Bellini et al. [17] (2019) | UK | 33 | 100 | 66 | 55 | – | 1 | 1 | 1 (100) | 0 (0) | 1 (100) | 0 (0) |
| Casteleijn et al. [18] (2022)* | The Netherlands | 134 | – | – | 66 | 53.5 | 4 | 4 | 4 (100) | 3 (75) | 1 (25) | 0 (0) |
| Gregoire et al. [19] (1987) | USA | 38 | 100 | 100 | 55 | 46 | 0 | – | – | – | – | – |
| Gupta et al. [10] (2022) | USA | 231 | 100 | 422 | – | – | 21 | 23 | – | 10 (43) | 9 (39) | 4 (17) |
| Hajj et al. [11] (2009) | France | 79 | 100 | 89 | 53 | 50 | 10 | 11 | 7 (64) | 6 (55) | 4 (36) | 1 (9) |
| Hansen et al. [20] (2015) | USA | 16 | – | – | 55 | 56 | 4 | – | 5 (100) | 4 (80) | 0 (0) | 1 (20) |
| Jilg et al. [6] (2013) | Germany | 240 | 100 | 301 | – | 54 | 11 | 12 | 7 (58) | 4 (33) | 7 (58) | 1 (8) |
| Kirkman et al. [21] (2011) | UK | 35 | 100 | 58 | 46 | – | 3 | 3 | 3 (100) | 2 (67) | 1 (33) | 0 (0) |
| Lubennikov et al. [22] (2021) | Russia | 108 | 100 | 216 | 56 | 55 | 7 | 7 | 7 (100) | 5 (71) | 2 (29) | 0 (0) |
| Mansbridge et al. [23] (2021) | Australia | 28 | – | 32 | 50 | 56 | 4 | 4 | 1 (25) | 1 (25) | 3 (75) | 0 (0) |
| Martin et al. [24] (2012) | USA | 37 | 100 | 74 | 51 | – | 3 | 3 | 1 (33) | 0 (0) | 2 (67) | 1 (33) |
| Patel et al. [25] (2011) | UK | 31 | 100 | 59 | 61 | 49 | 2 | 3 | 0 (0) | 1 (33) | 2 (67) | 0 (0) |
| Pfister et al. [26] (2010) | Germany | 40 | 100 | 51 | 65 | 59 | 3 | 3 | 0 (0) | 3 (100) | 0 (0) | 0 (0) |
| Veroux et al. [27] (2016) | Italy | 40 | 100 | 40 | 65 | 51 | 1 | 1 | 1 (100) | 0 (0) | 1 (100) | 0 (0) |
| Wagner et al. [28] (2007) | USA | 32 | 100 | 64 | 53 | 53 | 1 | 2 | 2 (100) | 0 (0) | 2 (100) | 0 (0) |
ADPKD, autosomal dominant polycystic kidney disease; ESRD, end-stage renal disease; n, number; RRC, renal cell carcinoma; UK, United Kingdom; USA, United States of America; –, not mentioned.
*Author contacted to obtain information regarding RCC subtype.
**Calculated as a percentage of total RCC’s detected in respective study.