Table 3.
Correlation between Xerna TME subtypes and other biomarkers
| Variable | Xerna TME classification | P1 | P2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IA (n = 4) | IS (n = 6) | A (n = 5) | ID (n = 7) | IA + IS (n = 10) | A + ID (n = 12) | ||||
| KRAS status, n (%) | 0.848 | 1.000 | |||||||
| Wild type | 7 (32) | 1 (25) | 2 (33) | 1 (20) | 3 (43) | 3 (30) | 4 (33) | ||
| Mutant | 15 (68) | 3 (75) | 4 (67) | 4 (80) | 4 (57) | 7 (70) | 8 (67) | ||
| PD-L1, n (%) | 0.730 | 1.000 | |||||||
| Negative | 10 (48) | 2 (67) | 2 (33) | 3 (60) | 3 (43) | 4 (44) | 6 (50) | ||
| Positive | 11 (52) | 1 (33) | 4 (67) | 2 (40) | 4 (57) | 5 (56) | 6 (50) | ||
| CD8 expression, n (%) | 0.326 | 0.231 | |||||||
| Low | 10 (45) | 1 (25) | 2 (33) | 4 (80) | 3 (43) | 3 (30) | 7 (58) | ||
| High | 12 (55) | 3 (75) | 4 (67) | 1 (20) | 4 (57) | 7 (70) | 5 (42) | ||
| Treg, n (%) | 0.049 | 0.087 | |||||||
| Low | 12 (57) | 0 (0) | 3 (50) | 5 (100) | 4 (57) | 3 (33) | 9 (75) | ||
| High | 9 (43) | 3 (100) | 3 (50) | 0 (0) | 3 (43) | 6 (67) | 3 (25) | ||
Xerna TME subtypes: angiogenic (A), immune active (IA), immune desert (ID), and immune suppressed (IS).
P1: comparison among TME subtypes.
P2: comparison between high immune score (IA + IS) and low immune score (A + ID).