Table 2.
Time Dependent Area under curve (AUC) of AI-CAC All Cardiac Chambers Volumetry vs. N-terminal pro-brain natriuretic peptide (NT-proBNP), Agatston CAC score, and 9 Clinical Risk Factors for 5-,10-, and 15-year prediction of heart failure (HF).
| 5 Years |
10 Years |
15 Years |
||||
|---|---|---|---|---|---|---|
| HF Events accrued over follow-up |
92 |
188 |
256 |
|||
| AI-CAC Model Comparison | AUC (95% CI) | P value | AUC (95% CI) | P value | AUC (95% CI) | P value |
| AI-CAC (AI-enabled All Cardiac Chambers Volumetry)a | 0.83 (0.79, 0.87) | – | 0.82 (0.79, 0.86) | – | 0.86 (0.82, 0.91) | – |
| Agatston CAC Score | 0.69 (0.65, 0.76) | 0.0004 | 0.71 (0.66, 0.75) | <0.0001 | 0.71 (0.68, 0.78) | <0.0001 |
| NT-proBNP | 0.79 (0.75, 0.84) | 0.2640 | 0.75 (0.71, 0.78) | <0.0001 | 0.74 (0.69, 0.77) | <0.0001 |
| Clinical Risk Factors Modelb | 0.79 (0.77, 0.85) | 0.5809 | 0.80 (0.76, 0.85) | 0.0857 | 0.85 (0.82, 0.90) | 0.4141 |
| Composite Model (Clinical Risk Factors + Agatston CAC Score + AI-CAC) Comparison | ||||||
| Composite Model | 0.86 (0.82, 0.92) | – | 0.85 (0.81, 0.90) | – | 0.89 (0.86, 0.94) | – |
| AI-CAC (AI-enabled All Cardiac Chambers Volumetry) | 0.83 (0.79, 0.87) | 0.0042 | 0.82 (0.79, 0.86) | 0.0004 | 0.86 (0.82, 0.91) | <0.0001 |
| Agatston CAC Score | 0.69 (0.65, 0.76) | <0.0001 | 0.71 (0.66, 0.75) | <0.0001 | 0.71 (0.68, 0.78) | <0.0001 |
| NT-proBNP | 0.80 (0.75, 0.84) | 0.0035 | 0.75 (0.71, 0.78) | <0.0001 | 0.74 (0.69, 0.77) | <0.0001 |
| Clinical Risk Factors Modelb | 0.82 (0.77, 0.87) | 0.0013 | 0.80 (0.76, 0.85) | <0.0001 | 0.82 (0.79, 0.85) | <0.0001 |
a
Adjusted by age, gender, body surface area (BSA). P-values are determined by the DeLong test in comparison to the AI-CAC all chambers model.
b
9 known risk factors: Age, gender, diabetes, current smoking, hypertension medication, systolic blood pressure, diastolic blood pressure, LDL cholesterol, HDL cholesterol.