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The developed whole-cell biosensor for detecting SARS-CoV-2 in human serum. (a) Workflow of the SARS-CoV-2 detection. (b) Calibration plots of the whole-cell biosensor for the detection of spike proteins (wild-type) in human serum. (c) Yeast-based ELISA method for the detection of spike protein (wild-type) in human serum. (d) The signal response of the whole-cell biosensor toward the spike proteins (8 μg/mL) from different SARS-CoV-2 variants in human serum.
