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Proteolytic cleavage of amyloid precursor protein by β site amyloid precursor protein cleavage enzyme (BACE) and presenilin-1, a candidate protein for γ-secretase. Inhibition of β or γ cleavage reduces production of β amyloid, which has been linked to Alzheimer's disease. D denotes conserved aspartic acid residues that are candidate active sites for cleavage
