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. 2024 Jun 6;38(7):1477–1487. doi: 10.1038/s41375-024-02287-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Visual summary of cumulative dose analysis. Colored squares represent cumulative dose relative to the largest trial. Green represents lower cumulative dose, yellow similar, and red higher cumulative dose. B Meta-analysis of 5-year event-free survival (%), C Meta-analysis of 5-year overall survival (%), D Overview of cumulative drug doses proportionate to the largest clinical trial, E Relative dose intensity during day 0-90, day 0 till start maintenance and maintenance therapy. VCR vincristine, HD-MTX high-dose methotrexate, LD-MTX low-dose methotrexate, AraC cytarabine, SR standard risk, MT maintenance therapy.