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. 2024 May 16;38(7):1522–1533. doi: 10.1038/s41375-024-02278-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Cumulative (A) BCR::ABL1^IS ≤1%, (B) MMR, (C) MR⁴, and (D) MR^4.5 in evaluable patients. IS International Scale, MMR major molecular response, MR⁴ BCR::ABL1^IS ≤0.01%, MR^4.5 BCR::ABL1^IS ≤0.0032%. ^a CIs are based on the Clopper–Pearson method. 95% CIs were used for all patients, and 90% CIs were used for ponatinib-pretreated and -naive patients. ^b The rate of MMR by week 24 was 42.2% (95% CI, 27.7–57.8%) in all patients, 57.9% (90% CI, 36.8–77.0%) in ponatinib-naive patients, and 30.8% (90% CI, 16.3–48.7%) in ponatinib-pretreated patients. ^c The rate of MMR by week 48 was 44.4% (95% CI, 29.6–60.0%) in all patients, 57.9% (90% CI, 36.8–77.0%) in ponatinib-naive patients, and 34.6% (90% CI, 19.4–52.6%) in ponatinib-pretreated patients. ^d The rate of MMR by week 96 was 48.9% (95% CI, 33.7–64.2%) in all patients, 68.4% (90% CI, 47.0–85.3%) ponatinib-naive patients, and 34.6% (90% CI, 19.4–52.6%) in ponatinib-pretreated patients.