Fig. 5. Classification of TP53 variants detected in CLL.

A classification algorithm showing the basic principles of assigning variants into pathogenicity/oncogenicity classes. A detailed version of the algorithm listing assistive tools and specific variants classified into respective categories can be found in Supplementary Figure 1. Databases instrumental in the interpretation of TP53 variants are listed in Supplementary Table S5. # Might be misclassified as synonymous or missense and listed as such in some databases. *Oncogenicity classification according to Horak et al. [90] is also acceptable. Occurrence according to the UMD database [82]. VUS variant of unknown significance.