Fig. 6. TP53 variants detected in CLL with respect to their type and interpretation.

Illustrative example based on data published in Malcikova et al. [6]. Common population variants have been excluded. A Breakdown based on assignment using proposed classification algorithm (color coding corresponds to Fig. 5). Concordant functional/non-functional: assessed by functional tests (Kato et al. [95], Giacomelli et al. [96] and Kotler et al. [97]). B Proportion of TP53 variants detected in CLL assigned to pathogenicity categories. VUS variant of unknown significance.