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. 2023 Jun 15;66(7):1497–1519. doi: 10.1007/s12033-023-00777-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Collections of scRNA-seq applications in uncovering tumor heterogeneity in different kinds of cancers. Mainly altered signaling pathways related to different cancers are demonstrated in pictures. A WNT/β-catenin signaling pathway related to lung cancer. B HIF1-α signaling pathway associated with breast cancer. C Jak-STAT signaling pathway correlated with ovarian cancer. D Mainly changed Notch signaling pathway in gastric cancer. E The TP53 signaling pathway commonly alters in all these four kinds of cancers mentioned