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. 2024 Jan 2;42(10):1581–1593. doi: 10.1038/s41587-023-02033-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — On the generated synthetic dataset, the FDP₊ and the true FDR were assessed for a varying number of artificial features on a dataset of n = 200 samples and 10 (upper panels), 25 (middle panels), or 50 (lower panels) informative features within p = 1000 features. The FDP₊ (red line) and the true FDR (black line) are shown as a function of the frequency threshold. Increasing the number of artificial features allows for a more accurate estimation of the reliability threshold (θ, red dotted line). Boxes in box plots indicate the median and interquartile range (IQR), with whiskers indicating 1.5 × IQR.