TABLE 1.
TIL recognize autologous tumor cellsa
Target | Blocking MAb | IFN-γ (pg/ml/106 cells) |
---|---|---|
Tumor | None | 0 |
TIL | None | 23 |
Tumor + TIL | None | 400 |
W6/32 | 400 | |
L243 | 20 |
Autologous cervical cancer cells harboring HPV33 were tested for T-cell recognition as determined by IFN-γ and IL-2 secretion by ELISA. TIL secreted IFN-γ, but not IL-2 in response to tumor cells, which could be blocked with the anti-DR-directed MAb L243. Blocking with the anti-DR-directed MAb clone B8.12.2 showed a similar result in a parallel experiment.