Table 3.

Binomial logistic regression analysis for the correlations of SII with SCAS and MAFLD risk.

Variable	Model 1		Model 2		Model 3
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
SCAS
Q1	Ref. (1.0)		Ref. (1.0)		Ref. (1.0)
Q2	1.43(1.23–1.88)	<0.001	1.12(1.09–1.16)	<0.001	1.16(1.10–1.23)	<0.001
Q3	2.91(1.87–4.51)	<0.001	1.27(1.04–1.54)	0.018	1.20(1.09–1.32)	<0.001
Q4	3.73(1.60–8.70)	0.002	3.01(2.01–4.52)	<0.001	2.44(1.66–3.56)	0.001
Per SD increase	2.80 (2.26–3.47)	<0.001	1.94(1.39–2.71)	<0.001	1.87(1.34–2.60)	<0.001
Ln (SII)	2.54(1.75–3.69)	<0.001	2.43(1.08–5.48)	0.032	2.26(1.23–4.13)	0.008
P for trend	<0.001		<0.001		<0.001
MAFLD
Q1	Ref. (1.0)		Ref. (1.0)		Ref. (1.0)
Q2	1.65(1.11–2.46)	0.013	1.27(1.14–1.40)	<0.001	1.13(1.07–1.21)	<0.001
Q3	2.58(1.74–3.94)	<0.001	1.96(1.22–3.16)	0.006	1.76(1.08–2.86)	0.024
Q4	4.06(3.38–4.89)	<0.001	3.26(1.43–5.52)	<0.001	2.98(1.98–4.49)	<0.001
Per SD increase	2.68(1.82–3.98)	<0.001	2.08(1.23–3.37)	0.003	1.85(1.30–2.62)	<0.001
Ln (SII)	3.82(2.14–6.87)	<0.001	2.92(1.59–5.35)	0.001	2.11(1.14–3.92)	0.017
P for trend	<0.001		<0.001		0.001

Model 1: adjusted for age, gender, diabetic duration, smoking, and drinking.

Model 2: further adjustments for cardiometabolic variables, such as systolic blood pressure, diastolic blood pressure, waist circumference, body mass index, glycated hemoglobin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, and homeostatic model assessment of insulin resistance.

Model 3: additional adjustments for liver functional variables like alanine aminotransferase and aspartate aminotransferase.

SII, Systemic immune-inflammation index; MAFLD, Metabolic dysfunction-associated fatty liver disease; SCAS, Subclinical carotid atherosclerosis.