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. 2024 Jun 28;14:14973. doi: 10.1038/s41598-024-65814-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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hEndoV can cleave poly-A tail containing inosine. (A) ³²P-labeled inosine-containing poly-A (i-poly-A) or poly-A substrates are shown. ³²P-labeled (B) i-poly-A substrates and (C) poly-A were incubated with indicated concentrations of hEndoV for 30 min. (D) The cleavage products were analyzed by denaturing 12.5% urea gel electrophorese. Abbreviations: hEndoV, human endonuclease V; P, phosphorus; rA, ribo-adenine; rI, inosine; i-polyA, inosine-containing poly-A; polyA, poly-A Representatives of three independent experiments are shown.