Skip to main content
. 2024 Jun 18;12:1404573. doi: 10.3389/fchem.2024.1404573

FIGURE 2.

FIGURE 2

Dynamic Mechanism Analysis of P21 Inhibition on the CCND1-CDK4 Complex. (A) RMSF Analysis: Different colors represent the distribution of RMSF across residues for different structures, and the colored blocks illustrate the differences in RMSF among different structures. (B) Covariance Matrix of CCND1 over 500 ns: Positive values indicate positive correlated motions between residues, while negative values indicate anticorrelated motions between residues. (C) Covariance Matrix of CCND1-CDK4 over 500 ns: Positive values indicate positive correlated motions between residues, while negative values indicate anticorrelated motions between residues. (D) Covariance Matrix of CCND1-CDK4-P21 over 500 ns: Positive values indicate positive correlated motions between residues, while negative values indicate anticorrelated motions between residues.