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Restoration of T cell immunity by inhibiting FcγRI receptor on TAMs. (A) Inhibition of TAMs capturing anti-PD-1 from T cells in a FcγRI-dependent manner. (B) Restore the killing effect of T cells on tumor cells and enhance the efficacy of anti-PD-1. TME, tumor microenvironment; PD-1, programmed cell death protein 1; PD-L1, programmed cell death 1 ligand 1; FcγRI, CD64, Receptor I for the Fc Region of Immunoglobulin G; TCR, T cell receptor; MHC, major histocompatibility complex.
