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. 2024 Jun 18;18:1375440. doi: 10.3389/fnins.2024.1375440

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Copyright © 2024 Melkumyan, Annaswamy, Evans, Showemimo, McCullers, Sun, Murphy, Vrana, Arnold, Raup-Konsavage and Silberman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main effects and interactions model between air control group and each of the withdrawal time groups in ratio of time spent immobile in the center. (A) Main effects of treatment, alcohol, stress, and sex in 4-h withdrawal. (B) Main effects of treatment, alcohol, stress, and sex in 24-h withdrawal. (C) Treatment by alcohol interaction of ratio of time spent immobile in the center stratified by stress in 4-h withdrawal. (D) Treatment by alcohol interaction of ratio of time spent immobile in the center stratified by stress in 24-h withdrawal. The p-values represent values of a statistical test of differences between the least square means outcome values for those combinations of explanatory factors. p < 0.05 is considered significant.